If I could choose only one FTSE 100 stock, this would be it

Mark Hartley considers which FTSE 100 stock would be the best option if he had to buy and hold only one forever. Is this pharma giant a clear winner?

| More on:
Engineer Project Manager Talks With Scientist working on Computer

Image source: Getty Images

When investing, your capital is at risk. The value of your investments can go down as well as up and you may get back less than you put in.

Read More

The content of this article is provided for information purposes only and is not intended to be, nor does it constitute, any form of personal advice. Investments in a currency other than sterling are exposed to currency exchange risk. Currency exchange rates are constantly changing, which may affect the value of the investment in sterling terms. You could lose money in sterling even if the stock price rises in the currency of origin. Stocks listed on overseas exchanges may be subject to additional dealing and exchange rate charges, and may have other tax implications, and may not provide the same, or any, regulatory protection as in the UK.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

Key Points

  • Up 76% in five years
  • Defensive stock with long-term resilience
  • High price-to-earnings (P/E) ratio of 34.9

When investing, the golden rule is to diversify. The FTSE 100 is full of stocks from different industries and sectors, each with their own unique value proposition. By mixing and matching a variety of stocks, I can protect myself from unexpected slumps in certain sectors.

However, for the sake of experimentation, I’m considering which stock I would pick if I were forced to choose only one. This exercise forces me to carefully evaluate the true potential of a company and its long-term growth prospects. I can’t just dump it on a whim — this would be a lifetime commitment!

So with that said, which stock would I pick?

Healthcare isn’t going anywhere

Out of all the stocks on the London Stock Exchange, I would have to choose AstraZeneca (LSE:AZN). The pharma giant made its name during the pandemic as one of the most rapid and successful developers of a Covid vaccine. With a £164bn market cap, it’s the second largest constituent on the FTSE 100 after Shell.

AstraZeneca has been on my radar for as long as I can remember. But recent performance has made me hesitant to buy. After the lingering effects of the pandemic wore off, the share price began to falter. It’s now down 10% in the past year to £105 from a high of £123 in April 2023. But a correction is expected following five years of solid growth that saw it add 76% to the share price.

Strength and resilience

The long-term value proposition of AstraZeneca is resilience during tough times. It has the key characteristic of a defensive stock — a service that is in high demand even during economic uncertainty.

Many pharmaceutical companies researched Covid but AstraZeneca stood out as a leader in advancing a vaccine. It’s a company with the resources and experience to excel when faced with a high-pressure situation. Covid is unlikely to be the last pandemic, and AstraZeneca is now well-positioned as a go-to option for governments seeking help.

Besides vaccine development, AstraZeneca is working on several breakthrough treatments. Tumour drugs Daiichi and Enhertu were recently approved in the US. People are living longer, so demand for such treatments is expected to increase. With a broad range of treatments, the company is less at risk of losses from a single product failure.

Risks and competition

Yet the pharmaceutical industry is very competitive and while AstraZeneca is leading in the UK, it could easily be outmatched. It faces stiff competition from the likes of AbbVie, Novartis and Pfizer. A recent plan to increase the CEO’s pay was branded necessary to remain competitive. But it was opposed by two influential shareholders, with others urged to follow suit.

At an eye-watering £105 per share, the price-to-earnings (P/E) ratio of 34.9 is considerably higher than the industry average of 24.9. This is also reflected in a high price-to-book (P/B) ratio of 5.3, above the industry average of 2.4 and a metric ideally kept below 1.

The high share price would understandably make AstraZeneca less attractive to many investors. However, I still feel it would be the best option if I had to choose and hold just one stock forever.

Should you invest, the value of your investment may rise or fall and your capital is at risk. Before investing, your individual circumstances should be assessed. Consider taking independent financial advice.

Mark Hartley has positions in Shell Plc. The Motley Fool UK has recommended AstraZeneca Plc. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Investing Articles

Here’s how I’d target passive income from FTSE 250 stocks right now

Dividend stocks aren't the only ones we can use to try to build up some long-term income. No, I like…

Read more »

Young mixed-race couple sat on the beach looking out over the sea
Investing Articles

If I put £10k in this FTSE 100 stock, it could pay me a £1,800 second income over the next 2 years

A FTSE 100 stock is carrying a mammoth 10% dividend yield and this writer reckons it could contribute towards an…

Read more »

Investing Articles

2 UK shares I’d sell in May… if I owned them

Stephen Wright would be willing to part with a couple of UK shares – but only because others look like…

Read more »

Investing Articles

2 FTSE 250 shares investors should consider for a £1,260 passive income in 2024

Investing a lump sum in these FTSE 250 shares could yield a four-figure dividend income this year. Are they too…

Read more »

A pastel colored growing graph with rising rocket.
Investing Articles

This FTSE share has grown its decade annually for over 30 years. Can it continue?

Christopher Ruane looks at a FTSE 100 share that has raised its dividend annually for decades. He likes the business,…

Read more »

Elevated view over city of London skyline
Investing Articles

Few UK shares grew their dividend by 90% in 4 years. This one did!

Among UK shares, few have the recent track record of annual dividend increases to match this one. Our writer likes…

Read more »

Investing Articles

This FTSE 250 share yields 9.9%. Time to buy?

Christopher Ruane weighs some pros and cons of buying a FTSE 250 share for his portfolio that currently offers a…

Read more »

Affectionate Asian senior mother and daughter using smartphone together at home, smiling joyfully
Investing Articles

As the NatWest share price closes in on a new 5-year high, will it soon be too late to buy?

The NatWest share price has climbed strongly so far in 2024, as the whole bank sector has been enjoying a…

Read more »