4 FTSE 100 shares to buy in a Stocks and Shares ISA

I think these FTSE 100 shares could be some of the best UK stocks to buy right now. Here’s why I’m thinking of adding them to my ISA.

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

I’ve been scouring the FTSE 100 for the best stocks to buy for my Stocks and Shares ISA. Here are several I think will deliver brilliant long-term returns to my UK share portfolio.

Surgical spirit

Demand for Smith & Nephew’s medical products slumped as the number of elective surgeries plummeted in the wake of Covid-19. However, things are looking up for the artificial joint and limb specialist as surgery volumes recover. The FTSE 100 firm is targeting underlying revenue growth of up to 13% this year. The uptick in coronavirus cases will surely come as some concern to the company and its investors. But I think the investment case for this UK healthcare stock remains extremely attractive thanks to Smith & Nephew’s cutting-edge products and strong sales growth in emerging markets. Underlying sales to developing regions rocketed 16.1% in 2019.

Orders are booming

The amount world governments spent on defence soared by 75% over the past two decades. This is explained in large part by military action in the Middle East and Afghanistan. While Western participation in these arenas is greatly reduced, all the signs are that BAE Systems’s products are likely to remain strong. Total spending on armaments hit its highest levels since the late 1980s last year.

BAE Systems too recorded total orders worth £20.9bn, up almost £2.5bn from 2019 levels. It’s true that the economic impact of a long battle against coronavirus could dent arms budgets in the short-to-medium term. But I’m not convinced Western governments will cut defence spending as the perception of a growing threat from China and Russia rumbles on.

Graph of price moves, possibly in FTSE 100

A tasty FTSE 100 choice

A bright outlook for the food delivery market provides terrific opportunities for FTSE 100 firm Domino’s Pizza Group, in my view. I think it’d be a mistake to assume that online delivery has peaked following recent Covid-19 lockdowns. Analysts at Lumina reckon the British foodservice delivery market will be worth £12.6bn in 2024, up from £11.4bn last year. It’s a trend I expect Domino’s to make huge profits from thanks to its market-leading brand and the investment it’s making in its store estate. I think it’s a great buy despite intense competition from the likes of Deliveroo and Just Eat.

The investing powerhouse

I’m not expecting the Bank of England to raise interest rates any time soon. Indeed, I think the recent Covid-19 surge on these shores will keep rates locked around record lows longer than most of us expected a few months ago. This bodes well for investment service providers like FTSE 100-quoted Hargreaves Lansdown as savers look for better ways to use their cash. The number of active clients on the firm’s books has doubled over the past five years and ended 2020 at 1.41m as low rates endured. I’m expecting rising concerns over the State Pension to fuel demand for its services, too, although a failure to keep up with its competitors in terms of its digital proposition could significantly harm future profits.

Royston Wild has no position in any of the shares mentioned. The Motley Fool UK has recommended Dominos Pizza, Hargreaves Lansdown, Just Eat Takeaway.com N.V., and Smith & Nephew. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Sunrise over Earth
Investing Articles

Meet the ex-penny share up 109% that has topped Rolls-Royce and Nvidia in 2025

The share price of this investment trust has gone from pennies to above £1 over the past couple of years.…

Read more »

House models and one with REIT - standing for real estate investment trust - written on it.
Investing Articles

1 of the FTSE 100’s most reliable dividend stocks for me to buy now?

With most dividend stocks with 6.5% yields, there's a problem with the underlying business. But LondonMetric Property is a rare…

Read more »

Investing Articles

Is 2026 the year to consider buying oil stocks?

The time to buy cyclical stocks is when they're out of fashion with investors. And that looks to be the…

Read more »

ISA coins
Investing Articles

3 reasons I’m skipping a Cash ISA in 2026

Putting money into a Cash ISA can feel safe. But in 2026 and beyond, that comfort could come at a…

Read more »

US Stock

I asked ChatGPT if the Tesla share price could outperform Nvidia in 2026, with this result!

Jon Smith considers the performance of the Tesla share price against Nvidia stock and compares his view for next year…

Read more »

Investing Articles

Greggs: is this FTSE 250 stock about to crash again in 2026?

After this FTSE 250 stock crashed in 2025, our writer wonders if it will do the same in 2026. Or…

Read more »

Investing Articles

7%+ yields! Here are 3 major UK dividend share forecasts for 2026 and beyond

Mark Hartley checks forecasts and considers the long-term passive income potential of three of the UK's most popular dividend shares.

Read more »

Hand is turning a dice and changes the direction of an arrow symbolizing that the value of an ETF (Exchange Traded Fund) is going up (or vice versa)
Investing Articles

2 top ETFs to consider for an ISA in 2026

Here are two very different ETFs -- one set to ride the global robotics boom, the other offering a juicy…

Read more »