Share your opinion and earn yourself a free Motley Fool premium report!

We are looking for Fools to join a 75 minute online independent market research forum on 15th / 16th December.

To find out more and express your interest please click here

Why Shire PLC’s Takeover Response Is Highly Unusual

After Abbvie’s £27bn takeover offer was rejected, Shire PLC (LON: SHP) has responded in a rather unusual way…

| More on:

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

shireJust over two months ago, shares in Shire (LSE: SHP) had made next to no gains in 2014. However, following various takeover rumours and then a bid from US healthcare giant, Abbvie, Shire has now posted capital gains of over 50% during the last six months. Great news for shareholders (especially when the FTSE 100 is up only 1% over the same timeframe).

However, things could be about to get a whole lot better for investors in Shire, since management in the company has outlined the sales potential of its pipeline in order, it says, to show Abbvie’s bid significantly undervalued the company.

Accurate Projections?

Of course, Shire’s decision to lay out the potential sales figures from its pipeline is unusual because outcomes from pipelines are notoriously difficult (if not impossible) to accurately predict. For example, a pharmaceutical company could have ten drugs in its pipeline, with all of them showing strong prospects in early stage trials. However, when more stringent trials are undertaken, a number of those drugs could fail to deliver when put under greater scrutiny and, more importantly, there seems to be only a limited scope to ascertain which ones could make it through clinical trials and become blockbusters.

In addition, while Shire may be accurate in its sales projections for its pipeline, it may not be able to accurately predict what other drugs will be marketed by the time its own drugs are approved. For example, Shire’s pipeline may contain two drugs that perform well throughout trials and are approved. However, a competitor may have a drug approved during that time that is either cheaper or performs better, thus sidelining Shire’s own, new drug.

Is Shire Worth More Than Its Current Share Price?

Having risen by 50% already this year, there could be better value elsewhere since Shire currently trades on a price to earnings (P/E) ratio of 22.6. This does not compare favourably to sector peers, GlaxoSmithKline (LSE: GSK) (NYSE: GSK.US) and AstraZeneca (LSE: AZN) (NYSE: AZN.US), which have P/Es of 15.2 and 17.5 respectively.

Furthermore, GlaxoSmithKline and AstraZeneca offer yields of 5.2% and 3.8%, while Shire’s yield of 0.4% is very low indeed. As with Shire, GlaxoSmithKline and AstraZeneca both have strong pipelines that could also prove to be targets for sector peers (as shown by Pfizer’s recent bid for AstraZeneca). Certainly, they may not be able to match Shire’s growth potential over the short term, but appear to offer sufficient diversity and resilience in their respective pipelines to ensure that they deliver impressive earnings growth in the long run.

As such, while Shire could yet be the recipient of further bids, GlaxoSmithKline and AstraZeneca could prove to be long-term winners for investors.

Peter owns shares in GlaxoSmithKline and AstraZeneca. The Motley Fool has recommended shares in GlaxoSmithKline and Shire.

More on Investing Articles

Investing Articles

Worried about a 2026 stock market slump? This ISA investment pays 4%+ with low risk

This type of low-risk fund could be an option to consider for ISA investors who are waiting for better stock…

Read more »

Two female adult friends walking through the city streets at Christmas. They are talking and smiling as they do some Christmas shopping.
Investing Articles

2 British income shares to consider before the Christmas boom

Our writer scoured historical market data to uncover which income shares typically do well in the run up to Christmas.…

Read more »

Rolls-Royce's Pearl 10X engine series
Investing Articles

Will Rolls-Royce shares continue their epic run into 2026 and beyond?

Noting that differences of opinion make the world go round, James Beard discusses what might happen to Rolls-Royce’s shares next…

Read more »

Investor looking at stock graph on a tablet with their finger hovering over the Buy button
Investing Articles

I asked ChatGPT if I’ve left it too late to buy Lloyds shares. Here’s what it said…

James Beard turns to artificial intelligence in an attempt to assess whether there’s any value left in Lloyds Banking Group…

Read more »

Man thinking about artificial intelligence investing algorithms
Investing Articles

7 moves I’ve just made in my Stocks and Shares ISA

I've been harvesting some gains recently in my Stocks and Shares ISA. Here are the four names I've been buying…

Read more »

Tabletop model of a bear sat on desk in front of monitors showing stock charts
Investing Articles

How on earth is this FTSE 100 stock up 319% in 2025?

It's been a barnstormer of a year for FTSE 100 stocks, but one unheralded mining firm is massively outperforming the…

Read more »

Night Takeoff Of The American Space Shuttle
Investing Articles

Will the Rolls-Royce share price double in 2026?

The Rolls-Royce share price remains one of the FTSE 100's best performers. Royston Wild asks if the engineer can do…

Read more »

Group of young friends toasting each other with beers in a pub
Investing Articles

Could ‘Drastic Dave’ save the Diageo share price in 2026?

Diageo will get a new boss on 1 January. But will the appointment of Sir Dave Lewis help reverse the…

Read more »