Should you ditch Neil Woodford after yet another investing disaster?

Neil Woodford has suffered yet another disaster, this time with US biotech stock Prothena. Is it time to ditch the portfolio manager?

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

It’s no secret that star fund manager Neil Woodford is having a dreadful run at the moment.

A number of Woodford-owned stocks have crashed spectacularly over the last year or so and that has had a significant impact on the portfolio manager’s performance. First there was Provident Financial, which lost around 70% of its market capitalisation in the blink of an eye after a nasty profit warning. Then Saga, which dropped over 30% after it, too, warned on profits. Then there was Capita, which plummeted 50% in January after suspending its dividend. Furthermore, there’s also been a number of slow-burning performance detractors, which have declined more steadily, such as Imperial Brands and AA, which are down around 40% and 50%, respectively, over the last year.

Overall, Woodford has underperformed many of his peers dramatically over the last year and, as a result, many investors have withdrawn capital from Woodford Investment Management.

If you were hoping that the worst was over for Woodford, I have bad news. Yesterday, the portfolio manager suffered yet another blow to his funds. Here’s a look at his latest investing disaster.

Another blow

Step forward US biotech company Prothena. This is a stock that Woodford has considerable exposure to across all three of his funds. At the end of March, the stock was the third largest holding in his Patient Capital Trust with a 9.1% weighting, the seventh largest holding in his Equity Income fund, at 3.1% of the portfolio, and the 23rd largest holding in his Income Focus fund, with a weighting of 1.8%.

That kind of exposure is going to hurt Woodford’s performance. As of yesterday, Prothena shares crashed nearly 70% after the failure of a crucial drug trial. The company advised that trials of its key drug NEOD001 – designed to treat a rare disease called AL amyloidosis – were unsuccessful and that it was halting development of the drug. The market clearly didn’t like the news and sent the shares crashing from $37 to $12. Woodford’s team stated that the results of the trial were “undoubtedly a blow” and that it would be working with the company and its management team on its strategy. Woodford’s Patient Capital Trust fell over 10% yesterday.

So, after this latest debacle, is it time to finally ditch Neil Woodford?

I’m out

Personally, I redeemed my SIPP holding in Woodford’s Equity Income fund back in February. The main reason I sold the fund was that it no longer represented the style of portfolio I was looking for.

Equity income funds should have a focus on dividend stocks. This type of fund generally invests in blue-chip stocks and is designed to provide regular income along with some capital growth. To my mind, there’s no place for a risky biotech company such as Prothena which pays no dividend.

Prothena is a better fit for Woodford’s Patient Capital Trust which invests in disruptive, early-stage companies. However, I won’t be investing in this fund as the performance track record is poor and I believe there are better alternatives. For example, over three years, the trust has returned -27%. In comparison, a growth fund I highlighted over the weekend, the Marlborough UK Micro-Cap Growth fund, has returned 72% in that time.

Edward Sheldon owns shares in Imperial Brands. The Motley Fool UK has recommended Imperial Brands. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Investing Articles

Is 2026 the year the Diageo share price bounces back?

Will next year be the start of a turnaround for the Diageo share price? Stephen Wright looks at a key…

Read more »

Investing Articles

Here’s my top FTSE 250 pick for 2026

UK investors looking for under-the-radar opportunities should check out the FTSE 250. And 2026 could be an exciting year for…

Read more »

Yellow number one sitting on blue background
Investing Articles

Here’s my number 1 passive income stock for 2026

Stephen Wright thinks a 5.5% dividend yield from a company with a strong competitive advantage is something passive income investors…

Read more »

Thoughtful man using his phone while riding on a train and looking through the window
Investing Articles

Should I sell my Scottish Mortgage shares in 2026?

After a strong run for Scottish Mortgage shares, our writer wonders if he should offload them to bank profits in…

Read more »

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

Down 35%! These 2 blue-chips are 2025’s big losers. But are they the best shares to buy in 2026?

Harvey Jones reckons he's found two of the best shares to buy for the year ahead, but he also acknowledges…

Read more »

A senior man and his wife holding hands walking up a hill on a footpath looking away from the camera at the view. The fishing village of Polperro is behind them.
Investing Articles

State Pension worries? 3 investment trusts to target a £2.6m retirement fund

Royston Wild isn't worried about possible State Pension changes. Here he identifies three investment trusts to target a multi-million-pound portfolio.

Read more »

Smiling white woman holding iPhone with Airpods in ear
Dividend Shares

4 dirt-cheap dividend stocks to consider for 2026!

Discover four great dividend stocks that could deliver long-term passive income -- and why our writer Royston Wild thinks they’re…

Read more »

Young mixed-race woman jumping for joy in a park with confetti falling around her
Investing Articles

These fabulous 5 UK stocks doubled in 2025 – can they do it again next year?

These five UK stocks have more than doubled investors' money as the FTSE 100 surges. Harvey Jones wonders if they…

Read more »