This S&P 500 stock could surge 55% in just 12 months, according to experts

One particular S&P 500 biotech continues to stink out our writer’s Stocks and Shares ISA. Is it time he chucked in the towel?

| More on:

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

piggy bank, searching with binoculars

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

Since joining the S&P 500 in July 2021, Moderna (NASDAQ: MRNA) stock has crashed by 92%. I think that counts as disastrous!

As a shareholder since 2022, I’m down nearly 80% on this position, including 67% in just the past year.

Recently then, I’ve been taking a cold, hard look at Moderna. If I cannot find reasons for optimism, I’ll sell up, take my loss on the chin, and move on. Here’s what I’ve found.

Why, why, why?

As many will remember, Moderna made its name during the pandemic when its mRNA vaccine was fast-tracked for use globally. The biotech firm went from just $35m in revenue in 2018 to over $19bn in 2022. All from a single product.

This year, though, Moderna is forecasting just $1.5bn to $2.2bn in revenue — and a steep loss — as it grapples with declining Covid vaccine sales. Some may say this was bound to happen as the pandemic faded, making my investment foolish.

So, why did I even buy the stock? Well, it related to pattern recognition. Some of my best investments have been made when the market underestimates a company’s potential to become something much more valuable.

Here are three examples from my portfolio:

StockHow it appearedThe potential I saw1-year return
Axon EnterpriseJust a Taser and body-cam companyA software-as-a-service powerhouse176%
Uber Ride-hailing app at risk of disruption by TeslaA potential super-app most robotaxis will run on49%
Games WorkshopNiche retailer for wargame hobbyistsAn IP-rich business with global growth opportunities56%

With Moderna, the market saw a one-trick pony with its Covid vaccine. I saw an mRNA technology platform that was potentially applicable to a wide range of diseases, including various cancers.

Since mRNA is an information-based platform, it works similar to a computer’s operating system, letting researchers insert new genetic code from a virus — like adding an app — to create a new vaccine quickly.

Moderna CEO Stéphane Bancel

Q2 update

Obviously, the only recognised pattern here has been a sliding share price. In hindsight, this makes my theory look silly.

Or does it? Because in its Q2 update, Moderna confirmed it’s still targeting another eight product approvals by 2028.

The most exciting candidates are in oncology, where it has Phase 2 and 3 trials across several cancer types, including adjuvant melanoma, non-small cell lung cancer, bladder cancer and renal cell carcinoma. 

Meanwhile, the firm’s flu vaccine recently delivered positive late-stage results, paving the way for a Covid‑flu combination vaccine.

Brokers forecast sales bottoming out this year. They then see revenue rising 20% next year to $2.3bn, followed by a further 25% jump to $2.9bn in 2027. Piper Sandler is more bullish, anticipating $4.3bn in sales by 2027 (more than double this year’s).

The biggest risk is that Moderna remains loss-making due to falling Covid sales and heavy investments in its late-stage pipeline. If its cancer vaccines ultimately disappoint, that would be a major setback.

However, the company still had $7.5bn in cash/equivalents last month. And due to cost-cutting, management says it’s on course to break even on a cash-cost basis by 2028.

My move

Weighing things up, I reckon more patience is required. So I’m going to keep holding (and praying).

Another glimmer of hope is that Wall Street’s price target of $42.85 is 55% higher than today’s level. Naturally, Moderna might never reach this, but it would be a nice boost.

Potential investors should know this is a high-risk, high-reward stock. It could generate fabulous returns from here, or flop further.

Ben McPoland has positions in Axon Enterprise, Games Workshop Group Plc, Moderna, and Uber Technologies. The Motley Fool UK has recommended Axon Enterprise, Games Workshop Group Plc, Moderna, Tesla, and Uber Technologies. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

British bank notes and coins
Investing Articles

Here’s a £30-a-week plan to generate passive income!

Putting a passive income plan into action need not take a large amount of resources. Christopher Ruane explains how it…

Read more »

Close-up of British bank notes
Investing Articles

Want a second income? Here’s how a spare £3k today could earn £3k annually in years to come!

How big can a second income built around a portfolio of dividend shares potentially be? Christopher Ruane explains some of…

Read more »

Close-up of British bank notes
Investing Articles

£20,000 for a Stocks and Shares ISA? Here’s how to try and turn it into a monthly passive income of £493

Hundreds of pounds in passive income a month from a £20k Stocks and Shares ISA? Here's how that might work…

Read more »

Snowing on Jubilee Gardens in London at dusk
Investing Articles

£5,000 put into Nvidia stock last Christmas is already worth this much!

A year ago, Nvidia stock was already riding high -- but it's gained value since. Our writer explores why and…

Read more »

Investing Articles

Are Tesco shares easy money heading into 2026?

The supermarket industry is known for low margins and intense competition. But analysts are bullish on Tesco shares – and…

Read more »

Smiling black woman showing e-ticket on smartphone to white male attendant at airport
Investing Articles

Can this airline stock beat the FTSE 100 again in 2026?

After outperforming the FTSE 100 in 2025, International Consolidated Airlines Group has a promising plan to make its business more…

Read more »

Investing Articles

1 Stocks and Shares ISA mistake that will make me a better investor in 2026

All investors make mistakes. The best ones learn from them. That’s Stephen Wright’s plan to maximise returns from his Stocks…

Read more »

Portrait Of Senior Couple Climbing Hill On Hike Through Countryside In Lake District UK Together
Investing Articles

I asked ChatGPT if £20,000 would work harder in an ISA or SIPP in 2026 and it said…

Investors have two tax-efficient ways to build wealth, either in a Stocks and Shares ISA or SIPP. Harvey Jones asked…

Read more »