Here’s where the AstraZeneca share price could end the year

Pharma hasn’t been in vogue this year. However, Dr James Fox believes a rotation out of technologies stocks could benefit the AstraZeneca share price.

| More on:

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

Two business people sitting at cafe working on new project using laptop. Young businesswoman taking notes and businessman working on laptop computer.

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

The AstraZeneca (LSE:AZN) share price is down 10% in a year. That’s clearly a disappointment for investors, and it marks a deviation from the positive trajectory of the past decade.

In that period, the stock’s moved from a little over £40 a share to nearly £110 today, so it’s been one of the UK’s most appealing growth stories.

But the company’s relative underperformance against UK stocks over 12 months can be traced to several things. One of these is a series of legal issues in China relating to claims of illegal drug importation.

Another factor is the US administration. The selection of Robert F Kennedy Jr to lead the health department saw pharma stocks pull back. After all, their biggest market was now under the administration of an alleged vaccine skeptic.

Further appointments have also been a cause for concern within the market. Controversial British doctor Aseem Malhotra was appointed as Chief Medical Adviser of the Make America Healthy Again campaign group in May, making him one of the US’s most influential medical advisers.

Tariffs and the odd medical trial disappointment have also contributed to this underperformance.

What could change?

So what’s in store? Well, there are several positives that may not have been priced into the stock. Firstly, Kennedy has taken a notably softer position on vaccines since his appointment, and that bodes well for one of the world’s largest vaccines and immune therapies developer.

AstraZeneca also seems well-positioned to mitigate against tariff impacts. The company already had a sizeable manufacturing presence in US but recently announced a further $50bn US investment plan.

However, I believe the stock market’s due a correction or rotation. The US market’s trading way above its 200-day average and the recent surge in markets has been driven largely by technology firms — where the global average price-to-earnings-to-growth (PEG) ratio has reached 1.81.

In short, I wouldn’t be surprised to see investors rotate their investments out of technology and into lesser valued areas of the market. Pharma, with its perennial draw that we will always need medicines, may be a net beneficiary.

And at 16 times forward earnings, AstraZeneca’s valuation is undemanding. The company’s net debt is manageable, the 2.2% dividend yield’s stronger than the sector average, and the forward PEG ratio represents a 25% discount to the mean.

It’s almost among the most positively-rated stocks on the FTSE 100. The are currently 15 Buy ratings, two Outperform ratings, and one Hold rating. The average share price target suggests the stock could be trading 26% higher.

Of course, the stock isn’t risk-free. The global trade environment isn’t ideal for AstraZeneca and neither is the US health secretary! However, if sentiment improves, I’d expect to the see the stock move towards that price target towards the end of the year, maybe hitting £125.

It’s a stock I may top up. It’s certainly worth considering for long-term investors.

James Fox has positions in AstraZeneca Plc. The Motley Fool UK has recommended AstraZeneca Plc. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Businessman hand stacking money coins with virtual percentage icons
Investing Articles

£5,000 invested in Tesco shares 5 years ago is now worth this much…

Tesco share price growth has been just part of the total profit picture, but can our biggest supermarket handle the…

Read more »

Investing Articles

Here’s why I’m bullish on the FTSE 100 for 2026

There's every chance the FTSE 100 will set new record highs next year. In this article, our Foolish author takes…

Read more »

Thoughtful man using his phone while riding on a train and looking through the window
Growth Shares

UK interest rates fall again! Here’s why the Barclays share price could struggle

Jon Smith explains why the Bank of England's latest move today could spell trouble for the Barclays share price over…

Read more »

Man hanging in the balance over a log at seaside in Scotland
Investing Articles

2 out-of-favour FTSE 250 stocks set for a potential turnaround in 2026

These famous retail stocks from the FTSE 250 index have crashed in 2025. Here's why 2026 might turn out to…

Read more »

Young female business analyst looking at a graph chart while working from home
Investing Articles

Down over 30% this year, could these 3 UK shares bounce back in 2026?

Christopher Ruane digs into a trio of UK shares that have performed poorly this year in search of possible bargains…

Read more »

Mature people enjoying time together during road trip
Investing Articles

Yields up to 8.5%! Should I buy even more Legal & General, M&G and Phoenix shares?

Harvey Jones is getting a brilliant rate of dividend income from his Phoenix shares, and a surprising amount of capital…

Read more »

Light trails from traffic moving down The Mound in central Edinburgh, Scotland during December
Investing Articles

Up 7.5% in a week but with P/Es below 8! Are JD Sports Fashion and easyJet shares ready to take off?

easyJet shares have laboured in 2025, but suddenly they're flying. The same goes for JD Sports Fashion. Both still look…

Read more »

US Stock

I think this could be the best no-brainer S&P 500 purchase to consider for 2026

Jon Smith reveals a stock from the S&P 500 that he feels has the biggest potential to outperform the index,…

Read more »