2 ‘unstoppable’ FTSE 100 shares I’d buy for a new ISA

The FTSE 100 includes some of the world’s best businesses. Our writer explores two high-quality picks that could bring long-term rewards.

| More on:

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

Finger clicking a button marked 'Buy' on a keyboard

Image source: Getty Images

ISA season has arrived. 6 April was the first day I could add fresh funds to my Stocks and Shares ISA.

But with new money sitting there, I’m looking at which shares to buy next. More specifically, I’m considering FTSE 100 shares.

FTSE 100’s best retailer

The first Footsie share on my hit list is UK fashion/lifestyle retailer Next (LSE:NXT). I used to own this share many years ago when it was trading at around £10. Since then, it has multiplied by a whopping nine times.

A £5,000 investment would now be worth £43,500. It’s a shame I didn’t hold onto it. But that’s in the past. Next has been and continues to be an impressive operator.

Its business strategy over the years has kept it ahead of the competition, in my opinion. For instance, it was one of the first among peers to make a push towards online sales.

Today, it continues to innovate. For instance, it now operates a Total Platform product which allows third-party brands to use Next’s infrastructure services such as IT, warehousing and marketing.

This could be a key driver of future growth, especially in a changing retail environment.

A high-quality business

Next shares offer many of the characteristics that make a quality stock. For instance, it offers a double-digit return on capital employed. It’s also a profitable business that churns out free cash flow.

This enables it to reduce debt and return excess cash to shareholders.

Bear in mind that retail consumers still face elevated cost of living pressures. Weather can also play a part in a customer’s shopping habits. And both factors can impact near-term earnings.

That said, these are short-term factors. For the long-term, I’m confident that Next will continue to be one of the leading retailers in the UK.

That’s why this time when I buy the shares, I hope I hold on to them.

The big pharma giant

Another quality FTSE 100 share I’d buy is pharmaceutical giant Astrazeneca (LSE:AZN). It’s the Footsie’s second largest company, one spot behind Shell.

Astrazeneca is a world-class player in this industry. Over the past decade it has focused on research and development. And it now offers a rich pipeline of innovative medicine across oncology, biopharmaceuticals and rare diseases.

If executed well, this should provide an excellent source of earnings growth for many years.

Oncology represents 35% of its portfolio and sales rose 23% last year. I’d note that chief executive Pascal Soriot expects “another year of strong growth in 2024, driven by continued adoption of medicines across geographies”.

Spending spree

Astrazeneca has purchased several billion-dollar companies recently. And although this could strengthen its pipeline, it doesn’t come cheap. Large acquisitions tend to come with some risk too. That said, this mega-cap has ample experience to lean on.

It trades on a forward price to earnings ratio of 16. This is broadly in line with peers, but I’d say it’s not expensive given its strong pipeline and potential.

Overall, both FTSE 100 top picks could prove to be unstoppable players in a long-term ISA. That’s why I intend to buy them both soon.

Harshil Patel has no position in any of the shares mentioned. The Motley Fool UK has recommended AstraZeneca Plc. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Long-term vs short-term investing concept on a staircase
Investing Articles

As the stock market goes crazy, here’s a FTSE 250 share I’m thinking about buying

The stock market has officially gone haywire, with the FTSE 100 entering correction territory today. Here's what I've got my…

Read more »

Three signposts pointing in different directions, with 'Buy' 'Sell' and 'Hold' on
Investing Articles

Load up on cheap shares now – or wait to see whether they get even cheaper?

As the market fluctuates, some shares may suddenly look cheap. How an investor acts in such moments can affect their…

Read more »

Close-up of British bank notes
Investing Articles

Is this a once-in-a-decade opportunity to target a second income?

Looking to make a large second income from UK dividend shares? Now might be the opportunity you've been waiting for,…

Read more »

Front view of a young couple walking down terraced Street in Whitley Bay in the north-east of England they are heading into the town centre and deciding which shops to go to they are also holding hands and carrying bags over their shoulders.
Investing Articles

What on earth is going on with Barratt Redrow shares?

Barratt Redrow shares are the FTSE 100's biggest faller over the last month. What has been going on with the…

Read more »

Close-up of British bank notes
Investing Articles

This UK penny stock is tipped to double by City analysts!

What should we do when a favourite penny stock falls due to short-term pressures? Consider buying for the long term,…

Read more »

Calendar showing the date of 5th April on desk in a house
Investing Articles

£390 of income a week from a £20k Stocks and Shares ISA? Here’s how!

Christopher Ruane explains how someone with a £20k Stocks and Shares ISA and long-term timeframe could target hundreds of pounds…

Read more »

Abstract 3d arrows with rocket
Investing Articles

Up 25% YTD! Is this red-hot penny stock still ‘cheap’?

This penny stock has been on fire in 2026. Ken Hall takes a closer look at the investment story behind…

Read more »

Man smiling and working on laptop
Investing Articles

Stock market correction? A passive income opportunity!

Looking to turbocharge your passive income? The stock market correction could be a once-in-a-decade chance to do just that, says…

Read more »