Share your opinion and earn yourself a free Motley Fool premium report!

We are looking for Fools to join a 75 minute online independent market research forum on 15th / 16th December.

To find out more and express your interest please click here

Will AstraZeneca plc, Shire plc and Smith & Nephew plc help you survive Brexit?

Should you buy these three stocks ahead of the EU referendum? AstraZeneca plc (LON: AZN), Shire plc (LON: SHP) and Smith & Nephew plc (LON: SN).

| More on:

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

With the EU referendum less than a month away, many investors may be feeling somewhat nervous regarding the prospects for the FTSE 100 and the UK economy. This is entirely understandable since there’s a real possibility that Brexit might happen, which could cause the investment community to become increasingly risk-off in the short run.

In such a scenario, owning defensive stocks could be a sound move. That’s because they’re likely to be less positively correlated to the performance of the UK economy, which means that their profitability is less dependent on the macroeconomic outlook than is the case for many of their index peers. As such, defensive stocks could become increasingly popular over the short-to-medium term and buying them now could be a means of outperforming a volatile index.

Positive growth outlook

One stock that appears to fit the bill in terms of its defensive characteristics is pharmaceutical business AstraZeneca (LSE: AZN). Certainly, its bottom line has disappointed in recent years due to the loss of patents on blockbuster drugs. But with AstraZeneca embarking on a takeover spree, its long-term profit growth outlook is relatively positive.

Furthermore, AstraZeneca’s future financial performance is more dependent on the performance of its drugs in clinical trials than the performance of the UK economy. And with it having a beta of 0.9, AstraZeneca should provide a less volatile shareholder experience, which could prove to be a useful attribute if the FTSE 100 becomes highly volatile following Brexit.

Reasonable price

Also offering an outlook less positively correlated with the UK economy than most of its index peers is Smith & Nephew (LSE: SN). It has the added advantage over most stocks (including AstraZeneca) in that its business model is very consistent and reliable. In fact, Smith & Nephew has been able to increase its earnings in each of the last five years and with earnings growth of 2% pencilled-in for this year as well as 12% for next year, investor sentiment towards the company could improve.

That’s especially the case since Smith & Nephew trades on a price-to-earnings growth (PEG) ratio of only 1.4, which indicates that its shares offer strong growth prospects at a very reasonable price.

The Baxalta issue

Meanwhile, Shire (LSE: SGP) has a rather less certain future than many of its pharmaceutical peers. That’s because it recently agreed to a $32bn acquisition of Baxalta and while this positions the company for long-term profits growth, there are concerns that synergies won’t be met and that the two companies will fail to integrate as successfully as hoped.

Clearly, such concerns are often present during major mergers and acquisitions. However, Shire’s PEG ratio of 0.9 indicates that they seem to be priced-in, with it having a relatively wide margin of safety. And with the company having a strong pipeline of new treatments, it could prove to be a star performer even if Brexit causes uncertainty in the short run for the FTSE 350.

Peter Stephens owns shares of AstraZeneca. The Motley Fool UK has recommended AstraZeneca. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Portrait of pensive bearded senior looking on screen of laptop sitting at table with coffee cup.
Investing Articles

From hero to zero: are Lloyds shares a ticking time-bomb after a 70% gain in 2025?

In 2025, Lloyds shares have produced around 10 years’ worth of average stock market gains. Could they be heading for…

Read more »

Young female business analyst looking at a graph chart while working from home
Investing Articles

Which stock market is best: the UK or US? Here’s how British investors can benefit regardless

Stock market diversification helps spread risk and capitalise on growth and income. Mark Hartley considers the options for British investors.

Read more »

Exterior of BT Group head office - One Braham, London
Investing Articles

Will the epic BT share price surge 77% in 2026?

BT's share price is tipped to rise next year. Discover what could drive the FTSE stock higher -- and what…

Read more »

Friends at the bay near the village of Diabaig on the side of Loch Torridon in Wester Ross, Scotland. They are taking a break from their bike ride to relax and chat. They are laughing together.
Investing Articles

I asked ChatGPT for 5 world-class UK stocks for a retirement portfolio. Here’s what it gave me

Searching for top-quality UK stocks for a retirement portfolio? Here are some names that the world's most popular generative AI…

Read more »

Happy male couple looking at a laptop screen together
Investing Articles

I just asked ChatGPT a really stupid question about FTSE 100 stocks and it said…

Harvey Jones insulted artificial intelligence by asking it a very basic question about which FTSE 100 stocks to buy and…

Read more »

Road trip. Father and son travelling together by car
Growth Shares

The share price of my favourite FTSE 100 growth stock can’t stop falling. Time to buy?

Paul Summers loves the near-monopoly this FTSE 100 company enjoys. But he's also concerned its shares have tumbled over 20%…

Read more »

UK coloured flags waving above large crowd on a stadium sport match.
Dividend Shares

Shock news: over 1 year, the FTSE 100 is beating the S&P 500!

For most of the last 15 years, the US S&P 500 index has thrashed the UK's FTSE 100. However, this…

Read more »

Aerial shot showing an aircraft shadow flying over an idyllic beach
Investing Articles

Why are investors flooding into IAG shares this week?

In the last week, investors have been snapping up IAG shares like there's no tomorrow. What could have sparked the…

Read more »