How Did AstraZeneca plc End Up Thrashing Rival GlaxoSmithKline plc?

AstraZeneca plc (LON: AZN) has handed out a real thrashing to pharmaceutical rival GlaxoSmithKline plc (LON: GSK) lately, but Harvey Jones suggests the tables could soon turn.

| More on:

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

A couple of years ago, AstraZeneca (LSE: AZN) (NYSE: AZN.US) was the whipping boy of the pharmaceutical world. Its drugs pipeline was drying up, patents were expiring and sales were plunging. The share price had gone nowhere for ages. Brokers were giving it a beating, with a spate of downgrades. Even currency movements were against it. Astra was under the cosh.

GlaxoSmithKline (LSE: GSK) (NYSE: GSK.US), by contrast, was the much-admired head boy of FTSE pharmo. It had won applause for its strategy of cutting costs and offloading non-core holdings. Its drugs pipeline looked healthy and chief executive Sir Andrew Witty’s strategy of shifting from “white pills and western markets” towards consumer healthcare and emerging markets had been awarded top marks.

Tables Turned

Then look what happened. Glaxo’s share price grew a disappointing 12% over the past two years, trailing the FTSE 100’s return of nearly 18%. AstraZeneca, however, returned a startling 44%. No longer the whipping boy, AZN now holds the whip hand. So what went right (or wrong)?

AZNGolden boy Glaxo’s reputation has been tarnished by bribery scandals, in China, Iraq and Poland, with more apparently set to follow Jordan and Lebanon. For those who think these allegations don’t matter, pharmaceuticals and vaccines sales in China have since fallen 29%. 

Glaxo has also faced a string of patented expiries and late-stage failures, notably megablockbuster heart drug Darapaldib and cancer vaccine MAGE-A3. Maybe the signs were on the wall in February, when Warren Buffett sold off his remaining $17 million stake.

Big Pharmo, Big Deals

AstraZeneca has been shining by comparison. Its drugs pipeline is growing, with 104 ongoing projects, of which 90 are in the clinical phase of development. Revenues rose 3% to $6.4 billion in the first quarter. Its five designated growth areas (emerging markets, Japan, Brilinta and its diabetes and respiratory franchises) delivered an extra $1.2 billion of revenue in 2013.

All of which is very nice, but it’s takeover talk that has really got investor juices flowing. Astra’s shares soared 7% in a day on rumours that it is a target for US giant Pfizer. 

This added to the excitement gripping the sector, following the multi-billion dollar three-way link-up between Glaxo, Swiss drugmaker Novartis and US medicines group Eli Lilly, who plan to build a world-leading consumer healthcare business. Investors love a deal, and Glaxo also leapt 6% in a day. Big pharmo deal making is back, with a vengeance, it seems. 

AstraZeneca may have turned the tables on Glaxo, but it may struggle to hold its advantage for investors, especially if recent takeover speculation comes to nought. Glaxo’s three-part deal could really drive future shareholder value, especially if it allows the company to dispose of some of its established businesses. Astra may have thrashed its rival lately, but I reckon Glaxo is cracking the whip today.

Harvey doesn't own shares in any company mentioned in this article. The Motley Fool has recommended shares in GlaxoSmithKline.

More on Investing Articles

Young woman working at modern office. Technical price graph and indicator, red and green candlestick chart and stock trading computer screen background.
Investing Articles

2 world-class S&P 500 stocks down 11% and 32% to consider buying

Searching for stocks to buy for an ISA in April? Our writher thinks these excellent growth shares are worth a…

Read more »

View over Old Man Of Storr, Isle Of Skye, Scotland
Investing Articles

How much do you need in a Stocks and Shares ISA to aim for an annual income of £39,477?

Harvey Jones shows how ordinary investors can use their Stocks and Shares ISA allowance to build a generous passive income…

Read more »

British flag, Big Ben, Houses of Parliament and British flag composition
Investing Articles

Wise: a hidden gem in the UK stock market

You won’t find Wise on the list of most popular shares in the British stock market. But Edward Sheldon believes…

Read more »

Rear view image depicting a senior man in his 70s sitting on a bench leading down to the iconic Seven Sisters cliffs on the coastline of East Sussex, UK. The man is wearing casual clothing - blue denim jeans, a red checked shirt, navy blue gilet. The man is having a rest from hiking and his hiking pole is leaning up against the bench.
Investing Articles

Is a £100,000 SIPP big enough to retire on?

Harvey Jones looks at how much money investors need in a SIPP to fund a decent standard of living after…

Read more »

British flag, Big Ben, Houses of Parliament and British flag composition
Investing Articles

As the FTSE 100 dips again, here’s what I think smart investors do next

FTSE 100 swings are creating short-term noise — but Andrew Mackie argues this may be where long-term opportunities are quietly…

Read more »

Investing Articles

This 67p growth stock’s smashing the FTSE 100 in 2026

This under-the-radar UK growth stock's absolutely flying right now. But it still sports a very reasonable valuation, says Edward Sheldon.

Read more »

Night Takeoff Of The American Space Shuttle
Investing Articles

Forget SpaceX? Amazon stock offers exposure to space cheaply

Amazon is the best performing Mag 7 stock in 2026. That's because investors are realising that there's huge potential in…

Read more »

Portrait Of Senior Couple Climbing Hill On Hike Through Countryside In Lake District UK Together
Investing Articles

How much does an investor need in an ISA to target £1,500 in monthly passive income?

Paul Summers reckons a bit of commitment and discipline can help generate a wonderful passive income stream for retirement.

Read more »