My Stocks and Shares ISA has two giant weeds in it. Should I pull them out?

This writer has two massive losers inside his Stocks and Shares ISA portfolio. What’s gone wrong? And is it time to sell up and move on?

| More on:

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

Middle-aged white man pulling an aggrieved face while looking at a screen

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

As I checked over my Stocks and Shares ISA portfolio at the weekend, two shares stood out. Not in a good way, unfortunately.

One FTSE 100 stock has plunged by 48% since I invested (twice!) last year, while the other is down 61%.

I’m now left wondering whether I should cut my losses and invest elsewhere.

A potential six-year wait

First up is Ocado (LSE: OCDO). Shares of the online grocer have fallen by a shocking 55% year to date.

This makes it the worst-performing Footsie stock of 2024, and it isn’t even close. In second-bottom place is St James’s Place, whose shares are ‘only’ down 29% year to date.

With a market cap of just £2.8bn, Ocado could soon be relegated to the mid-cap FTSE 250.

I invested because I’m bullish on its technology and robotic unit, which helps power the online operations of global grocers, including Kroger and Japan’s AEON.

Indeed, Ocado now has partnerships in seven of the world’s top 10 online grocery markets. This Technology Solutions division grew 44% in its last financial year.

However, the overall group remains unprofitable. It logged a £403m pre-tax loss last year. And its chief financial officer said it is expecting to make a pre-tax profit in the next six years.

Wow. That’s a long wait for potential profits, one which investors have clearly baulked at.

A misfiring business model

The second stock is Ginkgo Bioworks (NYSE: DNA). Shares of the synthetic biology company are down 71% in the past two years.

For those unfamiliar, Ginkgo programmes microbes on behalf of its customers. These include Novo Nordisk, Pfizer, and Merck.

Like Ocado, the firm is deeply unprofitable. It lost $178m in Q1. And while it added 17 new cell programs, representing 31% growth over the prior year, its $38m in revenue missed estimates by $8m.

Meanwhile, it lowered its full-year cell engineering services revenue guidance to $120m-$140m. That would be $1m year-on-year growth, at best.

For context, when the firm went public in 2021, it expected $628m from this segment.

This tells us the business model isn’t working. If you’re adding more programs from big pharma customers, but your revenue isn’t growing, then that is a serious problem.

To address this, management is cutting costs and changing how its contracts are negotiated.

One saving grace is that the company still had a $840m cash position at the end of the quarter. It is targeting adjusted EBITDA breakeven by the end of 2026.

Given the dreadful execution so far though, I’m not holding my breath.

Weeds and flowers

Warren Buffett is fond of quoting an analogy used by Wall Street legend Peter Lynch: “The weeds wither away in significance as the flowers bloom. Over time, it takes just a few winners to work wonders.”

Fortunately, along with these duds, I have stocks like Axon Enterprise, Games Workshop, and MercadoLibre. All have been wonderful long-term winners for me.

These flowers more than make up for the weeds!

Another Peter Lynch quote comes to mind here: “Selling your winners and holding losers is like cutting the flowers and watering the weeds.”

As things stand, I certainly won’t be watering these portfolio losers. In fact, I’m tempted to pull them out and invest in stocks with better prospects.

Ben McPoland has positions in Axon Enterprise, Games Workshop Group Plc, Ginkgo Bioworks, MercadoLibre, and Ocado Group Plc. The Motley Fool UK has recommended Axon Enterprise, Games Workshop Group Plc, MercadoLibre, and Novo Nordisk. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Young female business analyst looking at a graph chart while working from home
Investing Articles

Down over 30% this year, could these 3 UK shares bounce back in 2026?

Christopher Ruane digs into a trio of UK shares that have performed poorly this year in search of possible bargains…

Read more »

Mature people enjoying time together during road trip
Investing Articles

Yields up to 8.5%! Should I buy even more Legal & General, M&G and Phoenix shares?

Harvey Jones is getting a brilliant rate of dividend income from his Phoenix shares, and a surprising amount of capital…

Read more »

Light trails from traffic moving down The Mound in central Edinburgh, Scotland during December
Investing Articles

Up 7.5% in a week but with P/Es below 8! Are JD Sports Fashion and easyJet shares ready to take off?

easyJet shares have laboured in 2025, but suddenly they're flying. The same goes for JD Sports Fashion. Both still look…

Read more »

US Stock

I think this could be the best no-brainer S&P 500 purchase to consider for 2026

Jon Smith reveals a stock from the S&P 500 that he feels has the biggest potential to outperform the index,…

Read more »

Surprised Black girl holding teddy bear toy on Christmas
Investing Articles

Up 20% in a week! Is the Ocado share price set to deliver some thrilling Christmas magic?

It's the most wonderful time of the year for the Ocado share price, and Harvey Jones examines if this signals…

Read more »

Close-up as a woman counts out modern British banknotes.
Investing Articles

I asked ChatGPT for the 3 best UK dividend shares for 2026, and this is what it said…

2025 has been a cracking year for UK dividend shares, and the outlook for 2026 makes me think we could…

Read more »

Storytelling image of a multiethnic senior couple in love - Elderly married couple dating outdoors, love emotions and feelings
Investing Articles

£10k invested in sizzling Barclays, Lloyds and NatWest shares 1 year ago is now worth…

Harvey Jones is blown away by the performance of NatWest shares and the other FTSE 100 banks over the last…

Read more »

Investing Articles

£5,000 invested in these 3 UK stocks at the start of 2025 is now worth…

Mark Hartley breaks down the growth of three UK stocks that helped drive the FTSE 100 to new highs this…

Read more »