How Did AstraZeneca plc End Up Thrashing Rival GlaxoSmithKline plc?

AstraZeneca plc (LON: AZN) has handed out a real thrashing to pharmaceutical rival GlaxoSmithKline plc (LON: GSK) lately, but Harvey Jones suggests the tables could soon turn.

| More on:

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

A couple of years ago, AstraZeneca (LSE: AZN) (NYSE: AZN.US) was the whipping boy of the pharmaceutical world. Its drugs pipeline was drying up, patents were expiring and sales were plunging. The share price had gone nowhere for ages. Brokers were giving it a beating, with a spate of downgrades. Even currency movements were against it. Astra was under the cosh.

GlaxoSmithKline (LSE: GSK) (NYSE: GSK.US), by contrast, was the much-admired head boy of FTSE pharmo. It had won applause for its strategy of cutting costs and offloading non-core holdings. Its drugs pipeline looked healthy and chief executive Sir Andrew Witty’s strategy of shifting from “white pills and western markets” towards consumer healthcare and emerging markets had been awarded top marks.

Tables Turned

Then look what happened. Glaxo’s share price grew a disappointing 12% over the past two years, trailing the FTSE 100’s return of nearly 18%. AstraZeneca, however, returned a startling 44%. No longer the whipping boy, AZN now holds the whip hand. So what went right (or wrong)?

AZNGolden boy Glaxo’s reputation has been tarnished by bribery scandals, in China, Iraq and Poland, with more apparently set to follow Jordan and Lebanon. For those who think these allegations don’t matter, pharmaceuticals and vaccines sales in China have since fallen 29%. 

Glaxo has also faced a string of patented expiries and late-stage failures, notably megablockbuster heart drug Darapaldib and cancer vaccine MAGE-A3. Maybe the signs were on the wall in February, when Warren Buffett sold off his remaining $17 million stake.

Big Pharmo, Big Deals

AstraZeneca has been shining by comparison. Its drugs pipeline is growing, with 104 ongoing projects, of which 90 are in the clinical phase of development. Revenues rose 3% to $6.4 billion in the first quarter. Its five designated growth areas (emerging markets, Japan, Brilinta and its diabetes and respiratory franchises) delivered an extra $1.2 billion of revenue in 2013.

All of which is very nice, but it’s takeover talk that has really got investor juices flowing. Astra’s shares soared 7% in a day on rumours that it is a target for US giant Pfizer. 

This added to the excitement gripping the sector, following the multi-billion dollar three-way link-up between Glaxo, Swiss drugmaker Novartis and US medicines group Eli Lilly, who plan to build a world-leading consumer healthcare business. Investors love a deal, and Glaxo also leapt 6% in a day. Big pharmo deal making is back, with a vengeance, it seems. 

AstraZeneca may have turned the tables on Glaxo, but it may struggle to hold its advantage for investors, especially if recent takeover speculation comes to nought. Glaxo’s three-part deal could really drive future shareholder value, especially if it allows the company to dispose of some of its established businesses. Astra may have thrashed its rival lately, but I reckon Glaxo is cracking the whip today.

Harvey doesn't own shares in any company mentioned in this article. The Motley Fool has recommended shares in GlaxoSmithKline.

More on Investing Articles

This way, That way, The other way - pointing in different directions
Investing For Beginners

1 FTSE 250 stock I like and 1 I’ll avoid after the stock market correction

Jon Smith analyses the move lower in certain FTSE 250 companies over the past month and picks one that looks…

Read more »

Playful senior couple in aprons dancing and smiling while preparing healthy dinner at home
Investing Articles

Is April 2026 a great time to buy Lloyds shares?

Lloyds shares have been flying over the last two years. And there's one factor that could mean the bank continues…

Read more »

Young mixed-race couple sat on the beach looking out over the sea
Investing Articles

Want to aim for a £500 second income each month? Here’s how much it takes

Christopher Ruane digs into the numbers and mechanics that could let someone with no shares today build an annual second…

Read more »

Aston Martin DBX - rear pic of trunk
Investing Articles

Down 95%, what might it take for the Aston Martin share price to rise 2,000%?

The Aston Martin share price has collapsed. Our writer considers what it might take for it to regain some ground…

Read more »

Investing Articles

How are Diageo shares looking in April 2026?

It's been an eventful year so far, but what has the impact been for Diageo shares, and where might they…

Read more »

UK financial background: share prices and stock graph overlaid on an image of the Union Jack
Investing Articles

P/Es below 7! 3 staggeringly cheap shares despite yesterday’s rally

Investors who fear they have missed their opportunity to buy cheap shares as the stock market recovers might want to…

Read more »

ISA coins
Investing Articles

Want to know what UK investors have been buying in their ISAs?

Looking for stock, trust, and fund ideas this April? Royston Wild discusses what Brits have been stuffing in their Stocks…

Read more »

Mature Caucasian woman sat at a table with coffee and laptop while making notes on paper
Investing Articles

Why aren’t people buying Greggs shares by the bucketload?

Greggs' shares remain in the doldrums. But should Foolish investors consider pouncing while others won't? Paul Summers takes a fresh…

Read more »