Share your opinion and earn yourself a free Motley Fool premium report!

We are looking for Fools to join a 75 minute online independent market research forum on 15th / 16th December.

To find out more and express your interest please click here

Here’s why the GSK share price could be set to beat the FTSE 100

GlaxoSmithKline plc (LON: GSK) shares have been lagging the FTSE 100, but could 2018’s comeback mark a new upward trend?

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

Shares in GlaxoSmithKline (LSE: GSK) have put in a pretty unimpressive five years, dropping 12% — soundly beaten even by the FTSE 100’s lacklustre 15% rise.

But since the start of 2018, we’ve seen a 14% gain while the Footsie has remained flat, so are we set for a resurgence? If Wednesday’s second-quarter results are indicative of a new trend of earnings growth, then yes, I think we might finally be seeing the benefits of the investment the company has made in its drugs development pipeline.

We actually have already had a couple of years of EPS growth, but the flat couple of years expected ahead of us look to be holding investors back from their previous decades-long confidence in the company.

Narrow portfolio?

My colleague Harvey Jones has aired a warning over the dependence on a small number of key products, and the risk with that has been highlighted recently by the troubles facing Indivior — its one major product is already under threat from a generic drug manufacturer.

But Glaxo has some impressive offerings in addition to its current star HIV treatments on offer, though an update on FDA examination of its mepolizumab COPD offering on Thursday won’t have done it any favours. In short, though the vote went in favour of the safety of the drug, there was apparently not sufficient evidence of efficacy when used as an add-on treatment to inhaled corticosteroid-based products.

That doesn’t mean it’s dead, and further investigation into the population of sufferers who could benefit from the treatment might still lead to progress.

There also still seems to be some negative sentiment towards old-style pharmaceuticals giants from people who see nimble new biotechnology as being set to eclipse the blockbuster drugs model — especially the promise offered by genetics-based technology.

New technology

But I think that’s missing a very key point, and that’s that the drugs approval process is still a massively expensive enterprise. Upcoming new companies with promising ideas and interesting early results just don’t have the billions at their disposal for financing the process — and they rarely expect to go the whole way themselves anyway.

GlaxoSmithKline, of course, does have the cash, and that’s a key attraction of its partnership with 23andMe, which does genetic testing and analysis. 23andMe has built up a sizeable database of human genetic profiles. To a significant extent, that’s been driven by the benefits that genetic testing can offer to the increasingly popular genealogy market — find your ancestors and identify your possible genetic illnesses too.

Glaxo’s $300m investment in the firm looks like a canny move to me, and it could provide a very valuable set of data to contribute to computer modelling of the mechanisms of genetic conditions and how target drugs might work.

The world’s big pharmaceuticals companies are surely far more likely to benefit from new technology than to be threatened by it.

Buy or sell?

Even though Glaxo’s 11% share price loss over five years is disappointing, investors have also been enjoying dividends of 5%-6% per year. And that actually makes for a reasonable overall return, especially for those who reinvested their dividends when the share price was depressed.

A P/E close to the long-term FTSE 100 average of around 14, with forecast dividend yields of 5.2%? Looks good to me.

Alan Oscroft has no position in any of the shares mentioned. The Motley Fool UK owns shares of and has recommended GlaxoSmithKline. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Fans of Warren Buffett taking his photo
Investing Articles

No savings at 40? Use Warren Buffett’s golden rule to potentially build a £12,000 second income

Following Warren Buffett’s approach, I’ve learned how disciplined investing can grow a passive income – but only if hidden risks…

Read more »

Investing Articles

With silver soaring to $60, the Fresnillo share price is turning into a runaway express train

Fresnillo is the FTSE 100’s runaway leader in 2025. With silver surging past $60, can its share price keep defying…

Read more »

Portrait of pensive bearded senior looking on screen of laptop sitting at table with coffee cup.
Investing Articles

From hero to zero: are Lloyds shares a ticking time-bomb after a 70% gain in 2025?

In 2025, Lloyds shares have produced around 10 years’ worth of average stock market gains. Could they be heading for…

Read more »

Young female business analyst looking at a graph chart while working from home
Investing Articles

Which stock market is best: the UK or US? Here’s how British investors can benefit regardless

Stock market diversification helps spread risk and capitalise on growth and income. Mark Hartley considers the options for British investors.

Read more »

Exterior of BT Group head office - One Braham, London
Investing Articles

Will the epic BT share price surge 77% in 2026?

BT's share price is tipped to rise next year. Discover what could drive the FTSE stock higher -- and what…

Read more »

Friends at the bay near the village of Diabaig on the side of Loch Torridon in Wester Ross, Scotland. They are taking a break from their bike ride to relax and chat. They are laughing together.
Investing Articles

I asked ChatGPT for 5 world-class UK stocks for a retirement portfolio. Here’s what it gave me

Searching for top-quality UK stocks for a retirement portfolio? Here are some names that the world's most popular generative AI…

Read more »

Happy male couple looking at a laptop screen together
Investing Articles

I just asked ChatGPT a really stupid question about FTSE 100 stocks and it said…

Harvey Jones insulted artificial intelligence by asking it a very basic question about which FTSE 100 stocks to buy and…

Read more »

Road trip. Father and son travelling together by car
Growth Shares

The share price of my favourite FTSE 100 growth stock can’t stop falling. Time to buy?

Paul Summers loves the near-monopoly this FTSE 100 company enjoys. But he's also concerned its shares have tumbled over 20%…

Read more »