As AstraZeneca plc Slumps, Should You Sell And Buy Shire PLC?

Shire PLC’s (LON: SHP) future is bright, but AstraZeneca plc’s (LON: AZN) outlook is more uncertain.

| More on:

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

Shire (LSE: SHP) and AstraZeneca (LSE: AZN) couldn’t be more different. 

Shire’s growth is exploding, and investors are clamouring to get their hands on the company’s shares. Excluding exceptional items, the company delivered earnings growth of 38% last year. Further earning growth of 32% is expected this year.

And with this kind of growth on the cards, investors are willing to pay a premium to get their hands on Shire’s shares. Indeed, Shire currently trades at a forward P/E of 21.1 and is up 17.5% year to date. 

On the other hand, Astra’s shares have fallen by 8% year to date as investors turn their backs on the company. Astra’s earnings are expected to fall for the next two years, and the company currently trades at a forward P/E of 15. However, the company’s dividend yield of 4.4% is keeping some investors interested. 

Investor concerns 

Astra has fallen out of favour with the market during the past six months due to concerns regarding its research and development pipeline. Once touted as one of the best R&D pipelines in the industry, Astra is now falling behind as peers Roche, Bristol-Myers Squibb and Merck have all shown faster progress in bringing lung cancer treatments to market.

As a result, Astra has fallen behind in the development of new immuno oncology treatments and peers are stealing sales right from under its nose.

But to a certain extent, Astra is still a force to be reckoned with in the field of oncology. The company has more than 50 treatment trials planned for this year, with several launches planned between now and 2017. 

According to City analysts, three of these treatments have the potential to be blockbusters, which can return the company to growth by 2017; as targeted by management. 

And even though it has fallen behind its peers, Astra is expected to generate $6.9bn of oncology franchise sales by 2023, up from a low of $2.8bn reported this year. Profit margins are expected to expand significantly over this period. 

Unstoppable rise 

As Astra struggles, Shire is surging ahead. The company is snapping up smaller peers to boost growth and its treatment pipeline. 

What’s more, Shire’s flagship Vyvanse hyperactivity drug continues to report sales growth as the treatment’s user base expands. For example, at the beginning of this year the US Food and Drug Administration added binge eating disorder to the approved uses of Vyvanse.

Growth, income or value

Choosing between Astra and Shire is difficult, but in the end it comes down to your investing preference. If you’re looking for income with the potential for growth, Astra could be the best choice.

However, if you’re a growth investor who’s willing to sacrifice income and pay a premium for long-term growth, I’d say Shire is your best option. 

Rupert Hargreaves owns shares of AstraZeneca. The Motley Fool UK has no position in any of the shares mentioned. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Illustration of flames over a black background
Investing Articles

These 2 Stocks and Shares ISA buys are on fire in 2026

The new Stocks and Shares ISA season is seeing a few interesting changes to the companies making up investors' latest…

Read more »

Two white male workmen working on site at an oil rig
Dividend Shares

More oil wobbles as the BP share price dives 7% in a day!

The BP share price has been wildly volatile in 2026, bouncing around with each new move in the US-Iran war.…

Read more »

British bank notes and coins
Investing Articles

Meet the 9.6%-yielding income share that could keep growing its payout!

This income share yields close to 10% -- and has grown its dividend per share year after year for well…

Read more »

Fireworks display in the shape of willow at Newcastle, Co. Down , Northern Ireland at Halloween.
Investing Articles

When will Barclays shares hit £10?

Barclays shares were close to £1 not so long ago, but could they do the unthinkable and make it to…

Read more »

Picture of an easyJet plane taking off.
Investing Articles

easyJet shares have bounced back before. On a P/E ratio of 6, could they do it again?

Our writer thinks easyJet shares could turn out to be a terrific bargain from a long-term perspective. So is he…

Read more »

Stack of British pound coins falling on list of share prices
Investing Articles

Could National Grid shares offer me a dividend that won’t be hurt by inflation?

National Grid aims to inflation-proof its dividend per share with a policy of annual rises that match inflation. Is our…

Read more »

Young female business analyst looking at a graph chart while working from home
Investing Articles

Here’s what happened to £1,000 invested in the past 2 stock market crashes

History may not repeat itself, but our writer reckons there are lessons to be learned from what recent stock market…

Read more »

Young Caucasian woman at the street withdrawing money at the ATM
Investing Articles

Here’s how the HSBC share price reached an all-time high… and what might be next

HSBC’s record share price reflects a strong rebound in profits and investor confidence, but future gains may be bumpier from…

Read more »