Worried about buying at the top of the market? Look closer at this FTSE 100 giant

The FTSE 100’s largest stock could be one of the best value plays hiding in plain sight. Dr James Fox explains his optimism about the company.

| More on:
piggy bank, searching with binoculars

Image source: Getty Images

When investing, your capital is at risk. The value of your investments can go down as well as up and you may get back less than you put in.

Read More

The content of this article is provided for information purposes only and is not intended to be, nor does it constitute, any form of personal advice. Investments in a currency other than sterling are exposed to currency exchange risk. Currency exchange rates are constantly changing, which may affect the value of the investment in sterling terms. You could lose money in sterling even if the stock price rises in the currency of origin. Stocks listed on overseas exchanges may be subject to additional dealing and exchange rate charges, and may have other tax implications, and may not provide the same, or any, regulatory protection as in the UK.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

The FTSE 100 isn’t far off all-time highs. And while some investors may love that momentum, others will be a little worried about investing in a potentially stretched market.

The reality is that while some parts of the stock market are richly valued, especially US tech, it’s not universally the case.

In fact, I believe there are still great value plays to be had. One is AstraZeneca (LSE:AZN) — the largest company on the FTSE 100.

What makes the stock so great?

To start with, AstraZeneca’s forward price-to-earnings-to-growth (PEG) ratio of 1.2 is just 3% higher than its five-year average forward PEG.

What does that tell us?

Well, investors are currently quite used to paying more for a stock on a valuation basis than they did a couple of years ago.

This tells us that AstraZeneca is still pretty much the same price on a growth-adjusted metric.

But it’s not just on self-comparisons where AstraZeneca excels.

It’s a behemoth of the pharma and biotech world, and that means we should compare it against its global peers and not just those in the UK.

Sticking with the forward PEG ratio, we can see that the company is trading at a 35% discount to its global peers.

This is great sign of relative value. And it’s worth recognising that AstraZeneca supports this with a strong balance sheet and near-2% dividend yield.

While data can occasionally be misleading, the above figures tell me that this is a stock worth considering.

Business as usual

There have been several things weighing on the AstraZeneca share price over the past 12 months. A China scandal, a traditionally vaccine-wary US Secretary of Health and new tariff policy.

However, most of those concerns appear to be in the past. Earlier in October, AstraZeneca struck a landmark agreement with the US government to offer its drugs to Medicaid at “most-favoured-nation” (MFN) pricing. This means matching the lowest price it charges in other developed countries.

In turn, this means it’s really about business as usual for AstraZeneca. And that means focusing on a very large pipeline of treatments, drugs, and vaccines.

While it can take years to really dive into a company’s pipeline and assess how much value a drug or treatment may bring to patients and net sales, it’s also worth noting that many pipeline products never make it to market.

This, itself, is a risk that all investors must take when investing in pharma companies like AstraZeneca. It may spend billions on R&D but never see a penny for it.

However, the size of the portfolio does mitigate some of that risk. As does the company’s focus on advancing treatments in oncology and rare diseases — these are critical areas of medical development.

Personally, I think investors should be considering this FTSE 100 stock. It still looks cheap and it’s in an industry that isn’t going anywhere.


Should you invest, the value of your investment may rise or fall and your capital is at risk. Before investing, your individual circumstances should be assessed. Consider taking independent financial advice.

James Fox has positions in AstraZeneca Plc. The Motley Fool UK has recommended AstraZeneca Plc. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Arrow symbol glowing amid black arrow symbols on black background.
Investing Articles

The BT share price is tipped to blast through 200p! Can it?

Discover why City analysts think BT's share price has further to run -- and why our writer Royston Wild fears…

Read more »

Concept of two young professional men looking at a screen in a technological data centre
Investing Articles

ChatGPT and Gemini warn AI is a 7/10 threat to this FTSE 100 stock

If one artificial intelligence chatbot is to be believed, this high-quality FTSE 100 stock could be set to fall much…

Read more »

Portrait of pensive bearded senior looking on screen of laptop sitting at table with coffee cup.
Investing Articles

£10,000 invested in Diageo shares just last week is now worth…

Might Diageo finally be about to make long-suffering shareholders money again? Ben McPoland thinks the new CEO appointment is a…

Read more »

Smiling young man sitting in cafe and checking messages, with his laptop in front of him.
Investing Articles

Why did this hot FTSE 250 share just jump 15%?

This FTSE 250 stock is storming ahead after surprising the market with a nicely upgraded outlook for full-year revenue and…

Read more »

Fans of Warren Buffett taking his photo
Investing Articles

Here are 3 key lessons from Warren Buffett’s farewell letter 

Warren Buffett has been running Berkshire Hathaway since 1965, and in that time he boosted his shareholders' wealth many times…

Read more »

Two female adult friends walking through the city streets at Christmas. They are talking and smiling as they do some Christmas shopping.
Dividend Shares

How much do you need in a SIPP or ISA to target a second income worth £500 a week?

Creating a second income can transform retirement, and Harvey Jones recommends building a balanced portfolio of FTSE 100 dividend stocks…

Read more »

Frustrated young white male looking disconsolate while sat on his sofa holding a beer
Investing Articles

I was a huge fan of Greggs shares, then this happened…

After years of strong performance, Greggs shares have fallen off a cliff in 2025. But this writer thinks the FTSE…

Read more »

Finger clicking a button marked 'Buy' on a keyboard
Investing Articles

As the Vodafone share price jumps on H1 results, is this just the start?

The Vodafone share price is climbing back now the new CEO's transformation plans are bearing fruit. We've had a strong…

Read more »